Related topics: genes

Study shows how cells prevent harmful extra copies of DNA

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers. The work, published Jan. 5 in Molecular Cell, ...

MCM molecules impede the formation of DNA loops

The entire genomic material of a cell must be packed into a tiny cell nucleus in such a way, that on the one hand, it can be stored in an organized manner and, on the other hand, it can be transcribed, duplicated or repaired ...

Biologists discover a trigger for cell extrusion

For all animals, eliminating some cells is a necessary part of embryonic development. Living cells are also naturally sloughed off in mature tissues; for example, the lining of the intestine turns over every few days.

Transcription factors may inadvertently lock in DNA mistakes

Transcription factor proteins are the light switches of the human genome. By binding to DNA, they help turn genes 'on' or 'off' and start the important process of copying DNA into an RNA template that acts as a blueprint ...

DNA replication machinery captured at atom-level detail

July 15, 2019) Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. St. Jude Children's Research Hospital scientists have determined at atomic resolution the ...

A mutational timer is built into the chemistry of DNA

If you had to copy billions of letters from one sheet of paper to another, you'd probably make a few mistakes. So it might not come as a surprise that when DNA makes a copy of its three-billion-base genetic code, it can slip ...

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