Stunningly detailed blueprint revealed of viral genome replication machinery
RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.
RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.
Cell & Microbiology
Jan 24, 2023
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DNA replication is essential for living organisms to faithfully deliver genetic information from parental cells to daughter cells. Many proteins are assembled on the parental DNA to work as replication machineries. Among ...
Biotechnology
Jun 3, 2019
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Scientists reveal how a 'molecular machine' in bacterial cells prevents fatal DNA twisting, which could be crucial in the development of new antibiotic treatments.
Biochemistry
Nov 22, 2018
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Two major factors matter when it comes to cells copying DNA: getting everything accurate in the sequence and how much of it is replicated. Mistakes can result in mutations, which can lead to diseases such as cancer.
Cell & Microbiology
Oct 30, 2018
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If you had to copy billions of letters from one sheet of paper to another, you'd probably make a few mistakes. So it might not come as a surprise that when DNA makes a copy of its three-billion-base genetic code, it can slip ...
Cell & Microbiology
Jan 31, 2018
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A research collaboration between the Medical University of South Carolina, the Institute of Human Genetics in France, and Howard Hughes Medical Institute at Rockefeller University has revealed the means by which cells accomplish ...
Cell & Microbiology
Jun 14, 2016
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In a study published on 28 March 2016 in the Proceedings of the National Academy of Sciences, researchers at the Medical University of South Carolina (MUSC) and Virginia Commonwealth University have resolved the first protein ...
Biochemistry
Mar 28, 2016
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During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication ...
Biotechnology
May 4, 2015
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The molecular machines that copy DNA in a living cell are amazingly fast and accurate at pairing up the correct bases—G with C and A with T—into each new double helix.
Biochemistry
Mar 11, 2015
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The recent rise in antibiotic-resistant bacteria is a serious public health threat, and there is a need for new therapeutic strategies to combat these infections. A study published by Cell Press on November 14th in the journal ...
Cell & Microbiology
Nov 14, 2013
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