A new study in Science from Karolinska Institutet maps out how different DNA-binding proteins in human cells react to certain biochemical modifications of the DNA molecule. The scientists report that some 'master' regulatory ...
Biotechnology
May 4, 2017
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288
Structural biologists show in a new study that an apparently key step in the process of cell division depends on a unique interaction among specific proteins, including one that is strongly linked to cancer. Their hope now ...
Cell & Microbiology
Aug 30, 2016
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13
(Phys.org)—A team of researchers with Massachusetts General Hospital, Harvard Medical School and the Broad Institute has developed a procedure to decode histone modifications that point out gene regulation. In their paper ...
A new study shows that it is possible to use an imaging technique called cryo-electron microscopy (cryo-EM) to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells. The cryo-EM ...
Biochemistry
Jan 29, 2016
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20
The CRISPR-Cas9 system has been in the limelight mainly as a revolutionary genome engineering tool used to modify specific gene sequences within the vast sea of an organism's DNA. Cas9, a naturally occurring protein in the ...
Biotechnology
Sep 7, 2015
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115
In the biochemical game of genetics, it was thought that the proteins controlling gene regulation in animals were either spectators or players.
Biotechnology
Aug 25, 2015
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369
By tracking the movement of proteins in a living cell with nanometer-scale precision, Cornell researchers have gained a new insight into the way cells regulate the expression of their genes.
Cell & Microbiology
Jul 2, 2015
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21
Human chromosomes are much bigger and more complex than proteins, but like proteins, they appear to fold and unfold in an orderly process as they carry out their functions in cells.
Cell & Microbiology
Apr 28, 2015
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66
Research on a modified protein around which DNA is wrapped sheds light on how gene regulation is linked to aging and longevity in nematodes, fruit flies and possibly humans.
Cell & Microbiology
Apr 17, 2015
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47
A Simon Fraser University laboratory's breakthrough in understanding how a specialized sugar regulates protein levels in our cells could generate new targets for therapies to treat diseases caused by improper protein regulation. ...
Biochemistry
Mar 16, 2015
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26
