How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the disease and the targeted drug design. However, probing the molecular details of mutation-induced subtle ...
Biochemistry
Apr 16, 2024
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0
Photosynthetic bacteria (PSB), unlike plants, do not generate oxygen as a photosynthetic byproduct because they use hydrogen sulfide instead of water to convert solar energy into chemical energy (electrons). This process ...
Cell & Microbiology
Feb 19, 2024
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1
ABC transporters constitute a major class of multidrug resistance proteins, e.g., in cancer cells. Membrane lipids have been long known to influence the structure and functional dynamics of these proteins. However, previous ...
Molecular & Computational biology
Jan 3, 2023
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3
Researchers from the Skoltech Center for Molecular and Cellular Biology compared different protein structure prediction methods in terms of mutant protein stability evaluation and obtained the same result for the AI-predicted ...
Biotechnology
Aug 25, 2022
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5
A cutting-edge digital tool that will make it cheaper, safer and faster for pharmaceutical companies to predict protein stability—a vital step in the development of new medicines—is being rolled out by scientists from ...
Biochemistry
May 27, 2021
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8
A group of scientists led by EMBL's Mikhail Savitski, Nassos Typas, and Pedro Beltrao, and collaborator Steeve Boulant at Heidelberg University Hospital, have analyzed how the novel coronavirus affects proteins in human cells. ...
Cell & Microbiology
Feb 16, 2021
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5
Understanding how genes work and how they interact with one another is a major goal of biology. This poses huge challenges in terms of both methods and the sheer numbers of experiments required. Recent advances have transformed ...
Biotechnology
Dec 10, 2020
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29
NUS biophysicists have developed a manipulation assay that can quantify the mechanical stability and biochemical regulations of inter-molecular interactions at the single-molecule level.
General Physics
Feb 14, 2020
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94
Proteins make up a wildly diverse class of molecule, with key roles in everything from catalyzing reactions to helping fight off infection to transporting oxygen through the body. Now, Harvard scientists are beginning to ...
Cell & Microbiology
Jul 10, 2017
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3
In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular ...
Biochemistry
Feb 18, 2015
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