Protein domain structures affect the quality of stem cells

The original iPS cells were reprogrammed by transducing four genes: OCT3/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments ...

Research reveals features that influence phase separation

Scientists at St. Jude Children's Research Hospital and Washington University in St. Louis are dissecting the fundamental principles of biological phase separation, a process that is a major mechanism governing how cells ...

Artificial intelligence takes structural biology to the next level

A scientist at Karolinska Institutet reports that machine learning can be used to gain insights into molecular events that change the shape of proteins after they are made, regulating their ability to interact with each other. ...

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