Protein phosphorylation is a major posttranslational modification carried out by protein kinases that constitute an integral part of complex signaling networks in eukaryotes. Casein kinase 1 (CK1) is a conserved serine/threonine ...
Plants & Animals
Sep 28, 2023
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The instructions of life encoded in our genes are decoded through the translation into mRNA, which then instructs the synthesis of proteins. Because mRNA translation is an essential process, it is carefully coordinated through ...
Biotechnology
Feb 28, 2020
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The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. The study, ...
Cell & Microbiology
Dec 21, 2009
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Professor Hiroki Ueda, Assistant Professor Daisuke Tone, Lecturer Koji Ode, and Qianhui Zhang (4th-year graduate student at the time) at the University of Tokyo showed that CaMKIIβ, a predominant protein kinase expressed ...
Molecular & Computational biology
Oct 26, 2022
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7
Metabolic reaction flux change is the final result of interacting regulations by intracellular gene expression, transcriptional regulation, protein level, translation modification, and allosteric effect. However, the regulatory ...
Cell & Microbiology
Jun 20, 2023
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51
Every cell in the body uses phosphorylation, the process of adding a chemical tag to control a protein's function and fate, such as when it moves from one part of a cell to another or binds to other proteins.
Cell & Microbiology
Jun 18, 2015
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9
Coordinated activities of protein kinases and protein phosphatases ensure phosphorylation homeostasis and amplitude of signaling response, and understandably its imbalance is linked to diseases, such as cancer. Unlike with ...
Biochemistry
Mar 15, 2017
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Drought stress poses a significant challenge to plant survival, affecting growth and productivity. Transcription factors, particularly NAC proteins, play vital roles in plant responses to abiotic stress.
Molecular & Computational biology
Jun 17, 2024
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A team led by Prof. Dr. Han Sun from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has elucidated an important mechanism in the function of TREK channels at an atomic level. The results, published in ...
Molecular & Computational biology
Jul 10, 2024
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25
A recent paper published in Developmental Cell by the Matos Lab (formerly IBC, now Max Perutz Labs in Vienna) in collaboration with the Pilhofer Lab (IMBB), the Beltrao Lab (IMSB), and the Aebersold Lab (IMSB) unveils a phosphoproteomic ...
Cell & Microbiology
Jul 1, 2024
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