There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. ...
Biochemistry
Dec 4, 2018
0
71
Key insights into how the parasites behind sleeping sickness boost their ability to spread could aid efforts to beat the disease.
Cell & Microbiology
Nov 29, 2018
0
18
Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit ...
Biochemistry
Nov 22, 2018
0
70
An antibiotic called thanatin attacks the way the outer membrane of Gram-negative bacteria is built. Researchers at the University of Zurich have now found that this happens through a previously unknown mechanism. Thanatin, ...
Biochemistry
Nov 15, 2018
0
245
Researchers at the University of Eastern Finland have developed novel antibacterial compounds, focusing on the role of LsrK kinase. LsrK kinase is a protein involved in bacterial communication. In a new study published in ...
Biochemistry
Nov 1, 2018
0
73
Linking therapeutically active molecules to specific antibodies can help to pilot them to their designated targets and minimize side effects—especially when treating tumors. In the journal Angewandte Chemie, scientists ...
Biochemistry
Oct 30, 2018
0
7
One of the hallmark traits of Alzheimer's disease, a debilitating disorder marked by memory deficits and general cognitive decline, is the accumulation in the brain of a protein called b-amyloid. These proteins form "plaques" ...
Biochemistry
Oct 23, 2018
0
689
In 2013, Broad Institute member Cigall Kadoch, then a postdoctoral researcher at Stanford University, discovered that approximately 20 percent of all human cancers involve mutations in a group of proteins called BAF, a complex ...
Cell & Microbiology
Oct 22, 2018
0
18
Designing synthetic proteins that can act as drugs for cancer or other diseases can be a tedious process: It generally involves creating a library of millions of proteins, then screening the library to find proteins that ...
Biochemistry
Oct 16, 2018
0
81
The bacteria Pseudomonas aeruginosa can cause serious and difficult to treat infections. The infection process involves the activation of toxic substances from the bacteria by a common protein in our cells. Researchers at ...
Cell & Microbiology
Sep 17, 2018
0
37
