In a major advance for rational drug design, a Texas A&M AgriLife team has described several protein structures of a crucial player in cellular processes. The advance could bring new ideas for treatments of diseases such ...
Biochemistry
May 17, 2022
0
81
G protein-coupled receptors (GPCRs) play a crucial role in cell signal transduction and comprise the largest drug target protein family. Despite recent breakthroughs in structural and pharmacological studies of these receptors, ...
Cell & Microbiology
Apr 20, 2022
0
65
Cancer is simultaneously one of the most common and devastating diseases in our society. So working out new ways to treat it is an enduring scientific challenge.
Biochemistry
Mar 17, 2022
0
57
As mammals, we have very sensitive hearing, thanks to a process known as cochlear amplification. This amplification is down to sensory cells in the inner ear called outer hair cells (OHCs), and it is thought to depend on ...
Biotechnology
Jan 6, 2022
1
75
The original iPS cells were reprogrammed by transducing four genes: OCT3/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments ...
Cell & Microbiology
Dec 21, 2021
0
8
Proteins have been quietly taking over our lives since the COVID-19 pandemic began. We've been living at the whim of the virus's so-called "spike" protein, which has mutated dozens of times to create increasingly deadly variants. ...
Molecular & Computational biology
Jun 30, 2021
0
226
All plant cells obtain their energy mainly from two organelles they contain—chloroplasts (responsible for photosynthesis) and mitochondria (responsible for the biochemical cycle of respiration that converts sugars into ...
Biochemistry
Jun 21, 2021
0
1237
A study led by UT Southwestern has identified a mechanism that controls the activity of proteins known as chaperones, which guide proteins to fold into the right shapes. The findings, published online today in Nature Communications, ...
Molecular & Computational biology
Feb 11, 2021
0
174
Researchers from Duke-NUS Medical School in Singapore and Columbia University in the U.S. have solved how Wnt proteins, which play a fundamental role in cell proliferation and differentiation, hitch a ride to travel from ...
Cell & Microbiology
Jan 12, 2021
0
32
A research group from the Department of Biochemistry and Molecular Biology of the University of Valencia (UV), in coordination with the National Center for Biotechnology (CNB) of the CSIC, has studied the role of the interactions ...
Biochemistry
Nov 30, 2020
0
6
