Designed protein switch allows unprecedented control over living cells
Scientists have created the first completely artificial protein switch that can work inside living cells to modify—or even commandeer—the cell's complex internal circuitry.
Scientists have created the first completely artificial protein switch that can work inside living cells to modify—or even commandeer—the cell's complex internal circuitry.
Biochemistry
Jul 24, 2019
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634
A single-molecule imaging technique, called protein-induced fluorescence enhancement (PIFE), has gained traction in recent years as a popular tool for observing DNA–protein interactions with nanometer precision. Yet, according ...
Biochemistry
Jul 24, 2019
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35
The goal of the research, published July 11 in the journal Nature, was to engineer artificial proteins to self-assemble on a crystal surface by creating an exact match between the pattern of amino acids in the protein and ...
Biochemistry
Jul 10, 2019
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218
A team of researchers encoded their specialized knowledge into the computer game Foldit to enable citizen scientists to successfully design synthetic proteins for the first time.
Biochemistry
Jun 5, 2019
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765
Synthetic proteins have been created that move in response to their environment in predictable and tunable ways. These motile molecules were designed from scratch on computers, then produced inside living cells.
Biochemistry
May 16, 2019
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115
Proteins have now been designed in the lab to zip together in much the same way that DNA molecules zip up to form a double helix. The technique, whose development was led by University of Washington School of Medicine scientists, ...
Biochemistry
Dec 19, 2018
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108
For the first time, scientists have created, from scratch, self-assembling protein filaments.
Biochemistry
Nov 8, 2018
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56
Researchers at the University of Eastern Finland have developed novel antibacterial compounds, focusing on the role of LsrK kinase. LsrK kinase is a protein involved in bacterial communication. In a new study published in ...
Biochemistry
Nov 1, 2018
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73
It is now possible to create complex, custom-designed transmembrane proteins from scratch, scientists report this week. The advance, led by molecular engineers at the University of Washington Institute for Protein Design, ...
Biochemistry
Mar 1, 2018
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479
Scientists have created a high-speed method to generate thousands of different, small, stable proteins from scratch that can be custom-designed to bind to specific therapeutic targets.
Biochemistry
Sep 27, 2017
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331