EPFL scientists have created a new computer model that can help better design of allosteric drugs, which control proteins "at a distance".
General Physics
Feb 20, 2017
0
745
(Phys.org)—Protein folding is the process by which a polypeptide (a linear organic polymer chain consisting of many amino acid residues, or monomers) transforms from a random coil into the 3D conformation in which it can ...
A team of scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), led by Prof. Francisco Sánchez-Madrid, has characterized a cell signal that impedes intercellular communication and could ...
Cell & Microbiology
Nov 29, 2016
0
6
Inspired by the forms and functions of protein molecule machines and materials observed in nature, such as the shells that protect virus genomes, researchers have now engineered ten large, 120-subunit, two-component protein ...
Biotechnology
Jul 21, 2016
0
31
Chemists at UC San Diego have created an "adaptive protein crystal" with a counterintuitive and potentially useful property: When stretched in one direction, the material thickens in the perpendicular direction, rather than ...
Materials Science
May 02, 2016
0
16
Proteins are the molecules of life. They are chemically programmed by their amino acid sequence to fold into highly organized conformations that underpin all of biological structure (e.g., hair, scales) and function (e.g., ...
General Physics
Mar 21, 2016
0
427
Scientists at the Universities of York and Torino have used mathematics as a tool to provide precise details of the structure of protein nanoparticles, potentially making them more useful in vaccine design.
Mathematics
Feb 02, 2016
0
11
The potential of modular design for brand new proteins that do not exist in the natural world is explored Dec. 16 in the journal Nature. The reports are the latest in a recent series of developments toward custom-designing ...
Cell & Microbiology
Dec 16, 2015
0
8
Most pharmaceutical drugs consist of tiny molecules, which target a class of proteins found on the surfaces of cell membranes. Studying these subtle interactions is essential for the design of effective drugs, but the task ...
Biochemistry
Oct 23, 2015
0
920
A new study shows that it is possible to use an imaging technique called cryo-electron microscopy (cryo-EM) to view, in near-atomic detail, the architecture of a metabolic enzyme bound to a drug that blocks its activity. ...
General Physics
May 07, 2015
0
56
