Study uncovers secrets of a clump-dissolving protein

Workhorse molecules called heat-shock proteins contribute to refolding proteins that were once misfolded and clumped, causing such disorders as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. ...

Where does the pathological misfolding of the prion originate?

"When they are healthy, they look like tiny spheres; when they are malignant, they appear as cubes" stated Giuseppe Legname, principal investigator of the Prion Biology Laboratory at the Scuola Internazionale Superiore di ...

New technology for bioseparation

Separating target molecules in biological samples is a critical part of diagnosing and detecting diseases. Usually the target and probe molecules are mixed and then separated in batch processes that require multiple pipetting, ...

The ribosome: A new target for antiprion medicines

New research results from Uppsala University, Sweden, show that the key to treating neurodegenerative prion diseases such as mad cow disease and Creutzfeldt-Jakob disease may lie in the ribosome, the protein synthesis machinery ...

A new dimension for 3-D protein structures

(Phys.org) —3D structures of biological molecules like proteins directly affect the way they behave in our bodies. EPFL scientists have developed a new infrared-UV laser method to more accurately determine the structure ...

Prions can improve the health of fungal populations

(Phys.org) -- Prions, infectious agents composed of proteins with a specific misfolded and transmissible 3D structure that cuases diseases like BSE, can be present in fungal populations on a large scale, preventing the spread ...

Unravelling the mystery of misfolding prions

(Phys.org) -- Researchers at the University of Alberta's physics department and the National Institute for Nanotechnology (NINT) are the first to map out the folding pathways of prions, malformed proteins that ...

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