Altering pH bumps prions out of danger zone

Prion diseases are scary, incurable and fatal. They first gained notoriety when cows became infected by prion proteins and, in turn, infected people. Fervor surrounding mad cow disease resulted in the U.S. banning imports ...

Provocative prions may protect yeast cells from stress

Prions have a notorious reputation. They cause neurodegenerative disease, namely mad cow/Creutzfeld-Jakob disease. And the way these protein particles propagate—getting other proteins to join the pile—can seem insidious.

Revising the meaning of 'prion'

A team of Whitehead Institute and Stanford University scientists are redefining what it means to be a prion—a type of protein that can pass heritable traits from cell to cell by its structure instead of by DNA.

Prions can pass on beneficial traits, study finds

Prion proteins, best known as the agents of deadly brain disorders like mad cow disease, can help yeast survive hard times and pass the advantageous traits down to their offspring, according to a new study by researchers ...

Prion-like proteins found in mustard plant

(Phys.org)—A team of researchers affiliated with the Whitehead Institute for Biomedical Research, MIT and the Howard Hughes Medical Institute, all in Massachusetts has found a prion-like protein in Arabidopsis thaliana, ...

From good to bad with a copper switch

At the molecular level, the difference between Doctor Jekyll and Mr Hyde lies in a metal, copper. In its physiological form, the prion protein (PrPC ) is 'good' and is involved in normal body processes. It can happen, however, ...

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PRNP

More reference expression data

PRNP (PRioN Protein (Creutzfeld-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia)) is a gene that codes for a protein called the prion protein (PrP), which is expressed in the brain and several other tissues.

The human PRNP gene is located on the short (p) arm of chromosome 20 between the end (terminus) of the arm and position 12, from base pair 4,615,068 to base pair 4,630,233.

PRNP has also recently been designated CD230 (cluster of differentiation 230).

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