G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including ...
Biotechnology
Aug 10, 2023
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3
In drug delivery, the therapeutic behavior of the nanocarriers is limited by the "foreign" character of their surface. Despite the wide range of sophisticated coatings available, immune cells often identify these synthetic ...
Bio & Medicine
Jul 13, 2023
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31
In ongoing research aimed at developing more effective treatments for tuberculosis (TB), University of Massachusetts Amherst microbiologists have identified a long-sought gene that plays a critical role in the growth and ...
Cell & Microbiology
Apr 18, 2023
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3
Glycosylphosphatidylinositol (GPI) anchoring is an important post-translational modification, which tethers non-transmembrane proteins to the outer leaflet of the plasma membrane (PM). It participates in many biological processes ...
Plants & Animals
Aug 29, 2022
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18
Tomato (Solanum lycopersicum L.) is an economically important vegetable crop worldwide, and its production is threatened by temperature fluctuations and pathogen attacks, causing severe crop losses. In recent work published ...
Molecular & Computational biology
Aug 8, 2022
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7
In nature, there is a constant evolutionary battle between microbes and their hosts, during which many bacteria secrete specific proteins into the host's cells, aiming to alter its physiology while increasing pestiferous ...
Plants & Animals
Jun 3, 2022
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40
Lipid rafts, a component of the plasma membranes that surround all cells in the human body, are essential in regulating the membranes' structure, among other functions. But they are hard to study because traditional biochemical ...
Biochemistry
Mar 28, 2022
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25
Editor's note: In this interview, Nathan Ahlgren, assistant professor of biology at Clark University, uses 3-D-printed models to explain what proteins do in viruses, how they interact with human cells, how the vaccine delivers ...
Cell & Microbiology
Jan 26, 2021
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4
The small GTPases of the ADP-ribosylation factor (Arf) family are key initiators of various physiological processes including secretion, endocytosis, phagocytosis and signal transduction. Arf family proteins function to mediate ...
Biochemistry
Jan 6, 2021
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7
Chlamydia, a type of pathogenic bacteria, need to penetrate human cells in order to multiply. Researchers from Heinrich Heine University Duesseldorf (HHU) have now identified the bacterial protein SemC, which is secreted ...
Cell & Microbiology
Mar 5, 2020
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