(Phys.org)—Cytochrome P450 (CYP) is sometimes referred to as the "Rosetta Stone" of iron-containing oxygenases, because of its ubiquity as a biocatalyst for various reactions, including drug metabolism and synthesis of ...
Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory are giving scientists unprecedented access to a key class of proteins involved in drug detoxification.
Biochemistry
Dec 6, 2011
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Many plants, including crops, release volatiles in response to insect attack. The chemical compounds can be a defense or can be an aromatic call for help to attract enemies of the attacking insect. Researchers from Virginia ...
Plants & Animals
Nov 15, 2010
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Scientists led by Michael Green at Penn State University, have solved a 40-year-old puzzle about the mysterious process by which a critical enzyme metabolizes nutrients in foods and chemicals in drugs such as Tylenol, caffeine ...
Biochemistry
Nov 11, 2010
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Research led by Wayne L. Backes, PhD, Professor of Pharmacology and Associate Dean for Research at LSU Health Sciences Center New Orleans School of Medicine, has found that drug metabolism depends not only upon which enzymes ...
Biochemistry
Mar 17, 2010
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Polyploidy or whole-genome duplication (WGD) provides extra substrates for genomic evolution and is thus considered as an important driving force for genetic diversity, trait innovation, and ecological adaption. Despite extensive ...
Plants & Animals
Jul 14, 2022
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Cytochrome P450, family 17, subfamily A, polypeptide 1 (cyp17a1) is a critical enzyme involved in gonadal steroidogenesis, including androgen and estrogen production. Among sex steroids, androgen signaling disruption is known ...
Plants & Animals
Apr 15, 2022
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When agricultural weeds evolve resistance to herbicides, they do it in one of two ways. In target-site resistance, a tiny mutation in the plant's genetic code means the chemical no longer fits in the protein it's designed ...
Plants & Animals
Aug 16, 2021
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The human cytochrome P450 enzymes are responsible for metabolizing a variety of substances—from lipids (fats) and steroid hormones to drugs and toxic chemicals.
Biochemistry
Jun 14, 2019
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Researchers at the Novo Nordisk Foundation Center for Biosustainability in Denmark have developed a method of producing P450 enzymes used by plants to defend against predators and microbes in bacterial cell factories. The ...
Biotechnology
Jun 2, 2017
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