Strong painkillers are very important in the management of patients with cancer and heart attack or requiring surgery. They extert their effect by binding to so-called opioid receptors in the body.
Biochemistry
Mar 25, 2020
0
11
The U.S. opioid epidemic is being driven by an unprecedented surge in deaths from fentanyl and other synthetic opiates. Fentanyl's powerful effects are long-lasting, and even tiny amounts of the drug can lead to an overdose. ...
Bio & Medicine
Mar 31, 2019
1
238
Opioid drugs like morphine and fentanyl are a mainstay of modern pain medicine. But they also cause constipation, are highly addictive, and can lead to fatal respiratory failure if taken at too high a dose. Scientists have ...
Biochemistry
Jun 22, 2018
0
74
What if scientists could develop an opioid-based painkiller that is not addictive and has limited side effects?
Cell & Microbiology
Jan 5, 2018
49
4312
Drug discovery may bring to mind images of white lab coats and pipettes, but when Henry Lin, PhD, recently set out to find a better opioid with fewer side effects, his first step was to fire up the computers.
Biochemistry
Apr 6, 2017
0
9
Powerful opiate drugs are a mainstay in modern medicine, alleviating pain in both acute and chronic forms. These charms however, bear a curse. Users quickly develop tolerance to their effects, requiring ever-increasing doses ...
Biochemistry
Mar 2, 2015
0
612
Using a newly developed X-ray source, scientists have revealed how a new type of pain-relievers works - bonding to the same neuroreceptors that morphine does, but without the accompanying physical dependence.
Biochemistry
Feb 18, 2015
1
39
Researchers have long sought alternatives to morphine – a powerful and widely used painkiller – that curb its side effects, including dependency, nausea and dizziness. Now, an experiment at the Department of Energy's ...
Biotechnology
Feb 18, 2015
0
50
(Phys.org) —Almost every biological process involves sensing the presence of a certain chemical. Finely tuned over millions of years of evolution, the body's different receptors are shaped to accept certain target chemicals. ...
Bio & Medicine
May 6, 2014
0
0
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have described a pair of drug candidates that advance the search for new treatments for pain, addiction and other disorders.
Biochemistry
Jan 13, 2014
0
0
