Singling out a bacterium from the crowd

Bacteria are nearly ubiquitous and have tremendous impacts on human and ecological health. And yet, they remain largely mysterious to us. Princeton MOL faculty Zemer Gitai, Britt Adamson and Ned Wingreen launched a joint ...

Uncovering hidden mitochondrial mutations in single cells

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies ...

Team investigates sex-determination mechanisms in birds

Scientists have known that sex-determination in vertebrates happens in the germ cells, a body's reproductive cells, and the somatic cells, the cells that are not reproductive cells. Yet they have not fully understood the ...

New method boosts the study of regulation of gene activity

One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Methyl groups are one of these chemical modifications or tags. ...

New approach enables faster characterization of CRISPR immune systems

For many diseases, the tools of medicine are reaching their limits. CRISPR technologies open new avenues for diagnostics and therapies, although the natural source of CRISPR remains largely untapped. Scientists from the Helmholtz ...

Tracking the SARS-CoV-2 virus with genome sequencing

A study published in Cell Reports shows how next generation genetic sequencing can track mutations in the SARS-CoV-2 virus, which can in effect help with transmission tracing, diagnostic testing accuracy and vaccine effectiveness.

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