A 'door' into the mitochondrial membrane

Mitochondria—the organelles responsible for energy production in human cells—were once free-living organisms that found their way into early eukaryotic cells over a billion years ago. Since then, they have merged seamlessly ...

Researchers create most complete model of complex protein machinery

Environmental conditions, lifestyle choices, chemical exposure, and foodborne and airborne pathogens are among the external factors that can cause disease. In contrast, internal genetic factors can be responsible for the ...

Infectious disease may have shaped human origins, study says

An international team of researchers, led by scientists at the University of California, San Diego School of Medicine, suggest that inactivation of two specific genes related to the immune system may have conferred selected ...

Cancer is a p53 protein aggregation disease

Protein aggregation, generally associated with Alzheimer's and mad cow disease, turns out to play a significant role in cancer. In a paper published in Nature Chemical Biology, Frederic Rousseau and Joost Schymkowitz of VIB, ...

Missing link explains mRNA delivery in brain cells

Brain cells manufacture proteins in every corner, including their long branches. Neurons missing this ability cause severe neurological disorders like disability and epilepsy. The groups of Marino Zerial, Max Planck Institute ...

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