Researchers led by Prof. Zhang Zairong from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences have identified a post-translational topogenesis pathway for the folding and assembly of multi-spanning ...
Molecular & Computational biology
May 17, 2024
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1
Rice University's Peter Wolynes and his research team have unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve. Their paper was published May 13 in the Proceedings of the ...
Evolution
May 13, 2024
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125
How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the disease and the targeted drug design. However, probing the molecular details of mutation-induced subtle ...
Biochemistry
Apr 16, 2024
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0
Flowers may look delicate—but flowering plants, what scientists call angiosperms, are one of the most successful evolutionary organisms on the planet. Including more than 350,000 known species, they dominate the ecological ...
Evolution
Apr 10, 2024
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1
New research from the University of Wisconsin–Madison decodes the evolutionary pathway of regulatory proteins, the molecules that help control gene expression.
Evolution
Mar 29, 2024
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162
Enzymes, nature's remarkable biocatalysts, play an integral role in various aspects of daily life. Consider the awe-inspiring sight of fireflies lighting up a summer night. Their captivating glow serves not just to enchant ...
Biotechnology
Mar 20, 2024
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1
After the egg has been fertilized by a sperm, the surrounding egg coat tightens, mechanically preventing the entry of additional sperm and the ensuing death of the embryo. This is according to a new study led by researchers ...
Cell & Microbiology
Mar 14, 2024
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5
A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.
Cell & Microbiology
Dec 13, 2023
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26
The idea of irreversible inhibitors adhering permanently to a target protein has gained increasing attention for application in potential drug development. However, one of many hurdles is the possibility of protein mutations ...
Biochemistry
Nov 29, 2023
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20
Proteins, the workhorses of biology, are encoded by DNA sequences and are responsible for vital functions within cells. Since the first experimental measurement of a protein structure was made by John Kendrew in the 1950s, ...
Biotechnology
Nov 22, 2023
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