3D maps of diseased tissues at subcellular precision

Researchers in the Systems Biology Lab of Professor Nikolaus Rajewsky, at the Max Delbrück Center, have developed a spatial transcriptomics platform, called Open-ST, that enables scientists to reconstruct gene expression ...

Biophysicists decipher functionality of adrenaline-binding receptor

G protein-coupled receptors (GPCRs) are found throughout the human body and are involved in many complex signaling pathways. Despite their importance in many biological processes, the central mechanism of G protein-coupling ...

How E. coli defends itself against antibiotics

Imagine that you have a very sore throat. You're sick, your throat hurts, and a visit to the doctor confirms that the pain is due to a bacterial infection. You get a prescription for antibiotics, which quickly sorts out your ...

Scientists devise algorithm to engineer improved enzymes

Scientists have prototyped a new method for "rationally engineering" enzymes to deliver improved performance. They have devised an algorithm, which takes into account an enzyme's evolutionary history, to flag where mutations ...

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