Related topics: stem cells · genes · cells · cancer cells · immune system

Epigenetic mechanism appears to strongly influence healthy aging

Researchers at the Max Delbrueck Center for Molecular Medicine (MDC) have identified an epigenetic mechanism that appears to strongly influence healthy aging. It's a protein that controls muscle integrity, lifespan and levels ...

Mole rats are pain-free, thanks to evolution

African mole rats are insensitive to many kinds of pain. As an international research team led by the MDC's Gary Lewin reports in Science, this characteristic has allowed mole rats to populate new habitats. Thanks to a genetic ...

Welding with stem cells for next-generation surgical glues

Scientists at the University of Bristol have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. The new method, pioneered by Dr. Adam ...

On the origin of B1 cells

A new MDC study may resolve a decades-old debate in immunology. A team led by Professor Klaus Rajewsky reports in Science that distinct progenitor cells are not required for the development of B1 cells. Instead, the team's ...

A cause of possible genetic problems in mitochondria is revealed

A group of researchers from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) has revealed the importance of eliminating any excess of defective products that might have accumulated in the mitochondria, ...

Advancing the science of smell—with a hint of musk

Researchers have identified key molecular mechanisms at work when people smell musks, a highly valued group of fixatives used in many perfumes and colognes. The discovery may have implications for a wide range of effects ...

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Molecular medicine

Molecular medicine is a broad field, where physical, chemical, biological and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them. The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs.

In November, 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus Pauling, Harvey Itano and their collaborators laid the groundwork for establishing the field of molecular medicine. In 1956, Roger J. Williams wrote Biochemical Individuality, a prescient book about genetics, prevention and treatment of disease on a molecular basis, and nutrition which is now variously referred to as individualized medicine and orthomolecular medicine. Another paper in Science by Pauling in 1968, introduced and defined this view of molecular medicine that focuses on natural and nutritional substances used for treatment and prevention.

Published research and progress was slow until the 1970s' "biological revolution" that introduced many new techniques and commercial applications.

Molecular medicine is a new scientific discipline in European universities. Combining contemporary medical studies with the field of biochemistry, it offers a bridge between the two subjects. At present only a handful of universities offer the course to undergraduates. With a degree in this discipline the graduate is able to pursue a career in medical sciences, scientific research, laboratory work and postgraduate medical degrees.

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