A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies ...
Cell & Microbiology
Apr 13, 2023
0
45
Excavating ancient DNA from teeth, an international group of scientists peered into the lives of a once thriving medieval Ashkenazi Jewish community in Erfurt, Germany. The findings, shared today in the journal Cell, show ...
Archaeology
Nov 30, 2022
0
2337
Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial ...
Cell & Microbiology
Aug 25, 2022
0
4
Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases. The protein ...
Molecular & Computational biology
Aug 5, 2022
0
80
New mutations occur at increasing rates in the mitochondrial genomes of developing egg cells in aging rhesus monkeys, but the increases appear to plateau at a certain age and are not as large as those seen in non-reproductive ...
Molecular & Computational biology
Apr 4, 2022
0
252
Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are linked to diverse diseases. However, the precise mechanisms by which these mutations affect mitochondrial function and disease development are not fully ...
Molecular & Computational biology
Jan 3, 2022
0
11
One could say that mitochondria, the energy-producing organelles inside every human cell, dance to their own beat. After all, they have their own genome—a set of DNA-containing chromosomes—completely separate from the ...
Plants & Animals
Jul 9, 2020
0
67
Scientists can now precisely edit the genes inside mitochondria, the tiny energy factories inside of cells.
Biotechnology
Jul 8, 2020
1
294
New insight into how genetic information stored in human mitochondria is passed from one generation to the next could have important implications for genetic counseling of women planning pregnancies, according to a study ...
Biotechnology
Nov 18, 2019
0
300
Researchers at the University of Helsinki uncovered the mechanisms for a novel cellular stress response arising from the toxicity of newly synthesized proteins. Activation of the stress response is at the epicentre of the ...
Cell & Microbiology
Feb 22, 2019
0
2
