Team simulates how Alzheimer's disease spreads through the brain

For the first time, scientists have developed a computer simulation of how clumps of defective proteins in neurodegenerative diseases like Alzheimer's spread through the brain, much of the time in stealth mode, over as long ...

Scientists discover new function of heat-shock protein

An international research team has identified a new function of Hsp90, one of the most common and studied proteins in the human body. The study has implications for the development of new drugs.

Misfolded proteins serve as 'inherited memory' of toxic insults

Protein aggregates have a bad reputation in conditions such as Alzheimer's disease and Parkinson's disease, but in bacteria, inheritance of aggregates by daughter cells may help protect against the same toxic stresses that ...

Nanodiscs catch misfolding proteins red-handed

When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a structural snapshot of these proteins ...

Preventing protein unfolding

When the body loses its ability to fold proteins into the correct shapes, the result can be irreversible and tragic. The accumulation of unfolded or misfolded proteins in the brain causes many devastating neurodegenerative ...

A tale of two roads into protein unfolding

You are taking a class on origami and Mr. Otaki asks you to fold that little red piece of paper into a very elaborate design. You have to do it in a very short time. You try your best but you fail. Your origami sucks!

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