Protein determines life or death fate of stressed cells

Researchers discovered a new protein involved in the process that determines the fate of cells under stress and whether they fight to survive or sacrifice themselves for the greater good.

Now researchers can see how unfolded proteins move in the cell

When a large protein unfolds in transit through a cell, it slows down and can get stuck in traffic. Using a specialized microscope—a sort of cellular traffic camera—University of Illinois chemists now can watch the way ...

Cells put off protein production during times of stress

Living cells are like miniature factories, responsible for the production of more than 25,000 different proteins with very specific 3-D shapes. And just as an overwhelmed assembly line can begin making mistakes, a stressed ...

New probes quantify folded and misfolded protein levels in cells

Scientists at The Scripps Research Institute (TSRI) have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest ...

Tissue in trouble calls in reinforcements to restore health

Northwestern University scientists are the first to discover a cellular process used by animals when a tissue is stressed and in molecular trouble from the expression of misfolded and damaged proteins: The tissue at risk ...

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