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Regulation of secondary metabolite accumulation in medicinal plants

Medicinal plants are important economic crops and of great value in the health care industry. The rapid growth of market demand has led to a shortage of Chinese medicinal crops and an annual increase in prices. Secondary ...

Gut microbes' pathogen defense arsenal unveiled

A study conducted by researcher Juan Du's research group at the Karolinska Institutet sheds light on the capabilities of our gut microbes and their metabolites. The findings reveal potent inhibitory effects on the growth ...

Unlocking the mechanism of pineapple internal browning

Internal browning (IB) is a significant post-harvest issue in pineapples, impacting fruit quality and leading to substantial losses, yet its mechanism remains poorly understood. Studies have shown that the accumulation of ...

Root microbes may be the secret to a better tasting cup of tea

You'd think the complex flavor in a quality cup of tea would depend mainly on the tea varieties used to make it. But a study appearing in the journal Current Biology shows that the making of a delicious cup of tea depends ...

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Metabolite

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction. Alcohol is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

Examples of primary metabolites produced by industrial microbiology:

The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.

Metabolites from chemical compounds, whether inherent or pharmaceutical, are formed as part of the natural biochemical process of degrading and eliminating the compounds. The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Profiling metabolites of pharmaceutical compounds, drug metabolism, is an important part of drug discovery, leading to an understanding of any undesirable side effects.

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