About 30 percent of the proteins encoded by the human genome are membrane proteins—proteins that span the cell membrane so they can facilitate communication between cells and their environment. These molecules are critical ...
Biochemistry
Aug 28, 2018
0
110
If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in ...
Cell & Microbiology
Aug 15, 2018
0
2
For the first time, scientists have visualized the interaction between two critical components of the body's vast cellular communication network, a discovery that could lead to more effective medications with fewer side effects ...
Biochemistry
Jun 13, 2018
0
24
Using an informatics tool that identifies "hotspots" of post-translational modification (PTM) activity on proteins, researchers have found a previously-unknown mechanism that puts the brakes on an important cell signaling ...
Cell & Microbiology
May 7, 2018
0
74
As we are approaching the 100th anniversary of the discovery of insulin, a wide array of its signaling pathways has been defined. However, the initial step in insulin action, i.e. the engagement with its cell-surface receptor ...
Cell & Microbiology
Feb 20, 2018
0
7
A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time. The tiny proteins—approximately ...
Biochemistry
Feb 6, 2018
0
57
ETH chemists have synthesised several variants of THC, the active ingredient in cannabis. Its structure can be altered with light, and the researchers have used this to create a new tool that can be used to more effectively ...
Biochemistry
Jan 11, 2018
0
47
Scientists at The Scripps Research Institute (TSRI) have peered deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases. The protein, ...
Biochemistry
Dec 28, 2017
0
324
Using a revolutionary live-cell microscopy technique, an international team of scientist has for the first time observed individual receptors for hormones and drugs working in intact cells.
Biochemistry
Oct 19, 2017
0
190
UNSW researchers with the ARC Centre of Excellence in Advanced Molecular Imaging have built a sensor to measure the membrane charge of our T cells.
Biochemistry
May 1, 2017
0
215
