In most cases, antibiotics are a reliable form of protection against bacterial infections. They have saved billions of human lives since their introduction. This protection, however, is threatened by bacteria's resistance ...
Cell & Microbiology
May 16, 2024
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8
The opportunistic bacterial pathogen Pseudomonas aeruginosa is dangerous due to its resistance to multiple antibiotics. A research team from Heinrich Heine University Düsseldorf (HHU) and Jülich Research Center (Forschungszentrum ...
Biochemistry
May 13, 2024
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21
Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections—and, alas, extraordinarily difficult to target with drugs.
Biochemistry
Mar 7, 2024
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31
Vanderbilt scientist Houra Merrikh led a team of researchers who discovered the first anti-evolution chemical compound that prevents drug resistance development in bacteria. The compound is also a drug development platform ...
Biochemistry
Feb 29, 2024
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15
Scientists associated with the international software project MZmine, led by Dr. Robin Schmid and Dr. Tomáš Pluskal from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, have come up ...
Biochemistry
Dec 13, 2023
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40
It was a good year for research across multiple fields as a team at the University of Ottawa, working with colleagues Danilo Zia and Fabio Sciarrino, from the Sapienza University of Rome, demonstrated a novel technique to ...
When Senior Scientist Jonathan Grimm came to Janelia 13 years ago, he didn't know much about fluorescence or fluorescent dyes. But as an organic chemist who had been working in drug discovery at Merck, he certainly knew a ...
Analytical Chemistry
Dec 8, 2023
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20
Tylophorine has diverse biological activities; however, the stability, solubility, and central nervous system toxicity have severely limited use of tylophorine. The gem-dimethyl group is an organic chemistry functional group ...
Biochemistry
Oct 31, 2023
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17
Researchers at the Institute for Basic Science (IBS) in South Korea have made a groundbreaking discovery by identifying the structure and reactivity of rhodium-acylnitrenoid intermediates in catalytic hydrocarbon amination ...
Analytical Chemistry
Jul 20, 2023
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5
In chemistry, a molecule or ion is said to be chiral if it cannot be superposed on to its mirror image by any combination of rotations, translations, or conformational changes. A chiral molecule or ion exists in two forms, ...
Analytical Chemistry
Jul 6, 2023
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