Related topics: mass spectrometry · protein

A new imaging approach to see multiple proteins simultaneously

Researchers from Daegu Gyeongbuk Institute of Science and Technology (DGIST) have developed an innovative method to visualize up to tens of different proteins simultaneously in the same cell. This technology could help scientists ...

How do you weigh a single molecule?

Utrecht scientists have succeeded in measuring the mass of individual molecules. By modifying an existing mass spectrometer and developing special software, the researchers succeeded in making ultra-sensitive measurements. ...

NASA launching RiTS 'robot hotel' to International Space Station

Sometimes robots need a place to stay in space, too. NASA is attaching a "robot hotel" to the outside of the International Space Station with the upcoming launch of the Robotic Tool Stowage (RiTS), a protective storage unit ...

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Mass spectrometry

Mass spectrometry (MS) is an analytical technique for the determination of the elemental composition of a sample or molecule. It is also used for elucidating the chemical structures of molecules, such as peptides and other chemical compounds. The MS principle consists of ionizing chemical compounds to generate charged molecules or molecule fragments and measurement of their mass-to-charge ratios. In a typical MS procedure:

MS instruments consist of three modules: an ion source, which can convert gas phase sample molecules into ions (or, in the case of electrospray ionization, move ions that exist in solution into the gas phase); a mass analyzer, which sorts the ions by their masses by applying electromagnetic fields; and a detector, which measures the value of an indicator quantity and thus provides data for calculating the abundances of each ion present. The technique has both qualitative and quantitative uses. These include identifying unknown compounds, determining the isotopic composition of elements in a molecule, and determining the structure of a compound by observing its fragmentation. Other uses include quantifying the amount of a compound in a sample or studying the fundamentals of gas phase ion chemistry (the chemistry of ions and neutrals in a vacuum). MS is now in very common use in analytical laboratories that study physical, chemical, or biological properties of a great variety of compounds.

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