Scientists at EPFL have determined how a protein that is critical in our first line of immune defense is regulated in the cell to prevent autoinflammatory diseases.
Cell & Microbiology
Oct 25, 2022
0
33
Ferroptosis, an iron-dependent regulated cell death process driven by excessive lipid peroxides and membrane injury, can enhance cancer vulnerability to chemotherapy. Lipid peroxidation of unsaturated lipids (UL) in biological ...
Bio & Medicine
Oct 21, 2022
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13
Decades of studies on Drosophila vision have revealed multiple components required for the signaling events upon light stimulation. Light first turns on the photosensitive rhodopsin and, following several intermediate steps, ...
Cell & Microbiology
Oct 14, 2022
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46
Lipids—fats—make great walls for cells and organelles because they are water resistant and dynamic. But those same characteristics also make them hard to image using expansion microscopy, a technique that works for magnifying ...
Biochemistry
Oct 13, 2022
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32
Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), the most severe form of lipodystrophy that leads to loss of nearly all subcutaneous fat tissue, is caused by mutations in the BSCL2/seipin gene. Seipin is an integral ...
Cell & Microbiology
Oct 11, 2022
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7
Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells. The findings, ...
Cell & Microbiology
Sep 27, 2022
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52
University of Tennessee, Knoxville faculty members Shawn Campagna, professor and associate department head in chemistry, and Frank Loeffler, Governor's Chair professor in microbiology, have made a discovery that could lead ...
Biochemistry
Sep 23, 2022
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358
Thanks to high-throughput single-cell RNA sequencing (scRNA-seq), it is possible to construct single-cell transcriptomic atlases at the organic level. For example, cell atlases for vertebrate and invertebrate systems have ...
Cell & Microbiology
Sep 5, 2022
0
10
Glycosylphosphatidylinositol (GPI) anchoring is an important post-translational modification, which tethers non-transmembrane proteins to the outer leaflet of the plasma membrane (PM). It participates in many biological processes ...
Plants & Animals
Aug 29, 2022
0
18
Using UT Southwestern's Cryo-Electron Microscopy Facility, researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and crucial for Wnt signaling activation. The findings, reported ...
Biochemistry
Aug 16, 2022
0
18
