G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of ...
Molecular & Computational biology
Apr 15, 2019
0
7
Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.
Biochemistry
Apr 4, 2019
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7
The unicellular parasite that causes sleeping sickness differs from other eukaryotes in the mode of regulation of an essential cellular signaling pathway. This provides a promising point of attack for drug development.
Cell & Microbiology
Apr 3, 2019
0
6
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and ...
Biochemistry
Mar 20, 2019
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186
The cytoskeleton is a structure that not only helps cells maintain their shape and internal organisation, but also enables them to perform functions like movement and migration to sites far from the place where they originated. ...
Cell & Microbiology
Mar 12, 2019
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47
DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species. To detect and repair DNA lesions, cells have evolved DNA damage response. ...
Cell & Microbiology
Feb 27, 2019
0
4
Lysophospholipids (LysoPLs) are potent cellular signaling biomolecules that also maintain the structure, shape and fluidity of cell membranes.
Oncology & Cancer
Feb 18, 2019
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3
Cellular signaling pathways involved in everything from the proliferation of fatty tissue to the death of neurons in the brain are tightly regulated by "cascades" of sequentially activated enzymes, MAP kinases. These enzymes ...
Cell & Microbiology
Jan 21, 2019
0
4
Scientists at the UNC School of Medicine have discovered a crucial quality-control mechanism inside cells that, when it fails, might contribute to major diseases including cancers.
Cell & Microbiology
Dec 18, 2018
0
67
Scientists from VIB and Ghent University under the guidance of Prof. Dr. Jenny Russinova have uncovered a novel mechanism in plants that controls an important decision step in stomatal lineage to divide asymmetrically or ...
Plants & Animals
Nov 15, 2018
0
15
