Related topics: cancer cells

Scientists discover a novel FLT3-ITD mutant selective inhibitor

Recently, a research team led by Dr. Liu Qingsong and Dr. Liu Jing from High Magnetic Field Laboratory of the Chinese Academy of Sciences has discovered a novel FLT3-ITD mutation-selective kinase inhibitor CHMFL-FLT3-362, ...

Ancient origins of allosteric activation in the oldest kinases

One of the key features in the evolution of more complex organisms is the emergence of allosteric regulation. Allostery is a process by which a protein's activity can be modulated by binding an effector molecule distal to ...

Mathematical model reveals behavior of cellular enzymes

Everything a cell does, from dividing in two to migrating to a different part of the body, is controlled by enzymes that chemically modify other proteins in the cell. Researchers at Princeton University have devised a new ...

Skin cancer mystery revealed in yin and yang protein

It starts off small, just a skin blemish. The most common moles stay just that way—harmless clusters of skin cells called melanocytes, which give us pigment. In rare cases, what begins as a mole can turn into melanoma, ...

Antibiotics: New substances break bacterial resistance

Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a promising new class of active ingredients against resistant bacteria. In initial tests in cell cultures and insects, the substances were ...

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Kinase

In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases. Kinases are not to be confused with phosphorylases, which carry out phosphorolysis, the breaking of a bond using an inorganic phosphate group; or with phosphatases, which remove phosphate groups.

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