The hospital pathogen Pseudomonas aeruginosa requires the sugar-binding proteins LecA and LecB to form biofilms as well as to attach to and penetrate host cells. These so-called lectins are therefore suitable targets for ...
Biochemistry
Jan 16, 2023
0
37
Chronic pain is an extremely common condition that affects about 20% of the general population. Given the shortage of effective and non-addictive analgesics, new anti-pain drugs are eagerly awaited. Voltage-gated sodium channel ...
Molecular & Computational biology
Nov 28, 2022
0
2
A new collaborative study from the University of Eastern Finland, Washington University in St. Louis, University of Wisconsin–Madison, University of North Carolina at Chapel Hill and the Promega Corporation discloses the ...
Biochemistry
Nov 28, 2022
0
15
Researchers at the University of Illinois Chicago have found a small molecule capable of manipulating an immune process that plays an important role in cancers and autoimmune diseases.
Biochemistry
Oct 25, 2022
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96
While illegal for recreational use, psychedelic drugs are showing great promise as treatments for severe depression and anxiety, as well as alcohol addiction and other conditions. Some advocates and scientists believe the ...
Biochemistry
Sep 28, 2022
0
507
A team of Mount Sinai researchers has produced a high-resolution crystal structure of an enzyme essential to the survival of SARS-CoV-2, the virus that causes COVID-19. The discovery could lead to the design of critically ...
Molecular & Computational biology
Sep 8, 2022
0
65
New structural information about an enzyme target in cancer medicine could help the development of next generation inhibitors. The enzyme, called PARP1, senses DNA damage and sends a cellular signal to carry out repair. PARP1 ...
Biochemistry
Aug 16, 2022
0
65
Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumor during cancer. This molecule ...
Cell & Microbiology
Jul 27, 2022
0
13
The first full-length structures of the human angiotensin-converting enzyme (ACE) have been determined by researchers from the University of Cape Town (UCT) using cryo-electron microscopy (cryo-EM). ACE is a blood pressure-regulating ...
Biotechnology
Jul 12, 2022
0
40
Researchers led by Prof. Lin Wenchu from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences have proposed a mechanism by which circular RNA (circRNA) can promote the progression of small cell ...
Cell & Microbiology
Jul 6, 2022
0
14
