Probing how proteins pair up inside cells

Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of which interact with partner ...

Landing therapeutic genes safely in the human genome

Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called "genomic safe harbors (GSHs)." These are ...

In science, small groups create big ideas

In research and development, new topics are always emerging, maturing, and converging. Some of them quietly fade away, but others become the fundamental driving forces of innovation. Research organizations want to encourage ...

Researchers pioneer new method to edit genes in human cells

Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications. Now, researchers at Gladstone ...

Long reads and powerful algorithms identify 'invisible' microbes

Microbes are everywhere—in our guts, on our skin, permeating the environments around us. Studying these microbial communities has delivered tremendous insights into disease and good health, but identifying all the distinct ...

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