Flaws emerge in modeling human genetic diseases in animals

My lab, based at the University of Southern California Keck School of Medicine, uses zebrafish to model human birth defects affecting the face. When I tell people this, they are often skeptical that fish biology has any relevance ...

Fungal compound inhibits important group of proteins

Researchers in the group of Jeroen den Hertog, in collaboration with researchers in Leiden, have found that a compound inhibits a group of proteins called BMP receptors. This compound, called cercosporamide, was previously ...

Super-potent blood stem cells discovered in human embryos

Stem cells that form the blood and immune system, so-called hematopoietic stem cells (HSCs), have important applications in the treatment of blood cancers and other diseases of the immune system. Through blood stem cell transplantation, ...

Human embryo-like model created from human stem cells

Scientists from the University of Cambridge, in collaboration with the Hubrecht Institute in The Netherlands, have developed a new model to study an early stage of human development, using human embryonic stem cells. The ...

Histone modifications are the influencers of zygotic genome awakening

The zebrafish is an important model organism in biology. Humans and zebrafish share 70 percent of their genes, and more than 80 percent of human genes associated with disease are known to have a zebrafish counterpart. Additionally, ...

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Embryo

An embryo (irregularly from Greek: ἔμβρυον, plural ἔμβρυα, lit. "that which grows," from en- "in" + bryein "to swell, be full"; the proper Latinate form would be embryum) is a multicellular diploid eukaryote in its earliest stage of development, from the time of first cell division until birth, hatching, or germination. In humans, it is called an embryo until about eight weeks after fertilization (i.e. ten weeks LMP), and from then it is instead called a fetus.

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