Collaborating research groups in China have developed a novel technique, called DNA End tailing and sequencing (DEtail-seq), for meiotic DNA double-strand break (DSB) profiling.
Cell & Microbiology
Mar 2, 2023
0
4
Systematically attenuating DNA targeting activity can achieve CRISPR-driven editing in bacteria, greatly boosting colony counts and even increasing the frequency of precise genome editing. This was shown in a study of the ...
Cell & Microbiology
Feb 9, 2023
0
69
In the world of biomolecules, none is more iconic, nor more versatile, than DNA. Nature uses the famous double helix to store the blueprints of all living forms, drawing on a four-letter alphabet of nucleotides.
Bio & Medicine
Oct 4, 2022
0
48
DNA double-strand breaks are one of the biggest threats to the genome and a driving force of carcinogenesis. Cellular repair mechanisms such as homologous recombination are essential for the maintenance of genome stability ...
Cell & Microbiology
Aug 24, 2022
0
10
Unisexual reproduction lacks meiotic recombination, resulting in the accumulation of deleterious mutations and hindering the creation of genetic diversity. Thus, unisexual taxa are commonly considered an evolutionary dead ...
Evolution
Jul 11, 2022
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26
Synaptonemal complex (SC) assembly between paired homologous chromosomes plays a vital role in ensuring correct homologous recombination during meiosis. However, the mechanisms underlying the genetic regulation of SC assembly ...
Plants & Animals
Nov 10, 2021
0
33
In a study published in Nucleic Acids Research, the team of cancer researcher Francis Rodier, an Université de Montréal professor, shows for the first time that cellular senescence, which occurs when aging cells stop dividing, ...
Cell & Microbiology
Nov 9, 2021
0
218
BRCA1, a protein that is well-known for its role in hereditary breast cancer, is an important part of the cellular system that repairs double-strand DNA breaks. Now, researchers from Japan have discovered a new way in which ...
Biotechnology
Jul 13, 2021
0
11
Pichia pastoris (syn. Komagataella phaffii), a model methylotrophic yeast, can easily achieve high density fermentation, and thus is considered as a promising chassis cell for efficient methanol biotransformation. However, ...
Molecular & Computational biology
Jul 9, 2021
0
10
Scientists from the lab of Franz Klein from the Department of Chromosome Biology at the Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, have now discovered that cells sometimes ...
Cell & Microbiology
Jun 9, 2021
0
8
