(PhysOrg.com) -- DNA is under constant attack, from internal factors like free radicals and external ones like ionizing radiation. About 10 double-strand breaks – the kind that snap both backbones of the double helix ...
Cell & Microbiology
Apr 19, 2011
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Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing ...
Cell & Microbiology
Jan 21, 2013
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Double-strand breaks in DNA happen every time a cell divides and replicates. Depending on the type of cell, that can be pretty often. Many proteins are involved in everyday DNA repair, but if they are mutated, the repair ...
Cell & Microbiology
Feb 03, 2013
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Dividing cells are prone to errors, and so they must be prepared to summon sophisticated emergency systems to deal with potential damage. One type of division-derailing mishap can occur when assault by certain chemicals causes ...
Cell & Microbiology
Aug 07, 2015
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In a study published in Nucleic Acids Research, the team of cancer researcher Francis Rodier, an Université de Montréal professor, shows for the first time that cellular senescence, which occurs when aging cells stop dividing, ...
Cell & Microbiology
Nov 09, 2021
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(Phys.org)—A small team of researchers in the U.S. has built a detailed map that shows the sites where human genetic information is swapped between chromosomes. In their paper published in the journal Science, the team ...
One of the worst things that can happen to a cell is to end up with the wrong number of chromosomes. This can happen if something goes wrong during cell division, and it can lead to infertility, miscarriages, birth defects, ...
Cell & Microbiology
Oct 04, 2018
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As eggs and sperm, or gametes, are formed during meiosis, chromosomes carrying the genetic material from each parent must find their partners, pair, and exchange parts of their DNA. This recombination is an important driving ...
Biotechnology
Mar 17, 2016
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Homologous recombination is an essential process of DNA repair to maintain genomic integrity of the organism. Now, researchers from Japan have identified mechanisms that choose between alternate pathways of DNA repair to ...
Evolution
Apr 30, 2020
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(Phys.org)—A small team of researchers with the University of California has developed a way to use CRISPR/Cas9 to mimic mitotic recombination in yeast cells leading to a new way to map out genes and by doing so, determine ...
