Packaging and unpacking of the genome

DNA represents a dynamic form of information, balancing efficient storage and access requirements. Packaging approximately 1.8m of DNA into something as small as a cell nucleus is no mean feat, but unpacking it again to access ...

Plants defend their territory with toxic substances

Plants are stakeholders in a subtle and complex chemical warfare to secure optimal growth conditions. Although it has been known for decades that plants produce and release chemical substances to fight their neighbors, it ...

New DNA research reveals undiscovered white dots on the map

Researchers at the University of Copenhagen have located a previously unknown function in the so-called histones, which allows for an improved understanding of how cells protect and repair DNA damages. This knowledge may ...

Cell aging slowed by putting brakes on noisy transcription

Working with yeast and worms, researchers found that incorrect gene expression is a hallmark of aged cells and that reducing such "noise" extends lifespan in these organisms. The team published their findings this month in ...

New tool brings standards to epigenetic studies

One of the most widely used tools in epigenetics research - the study of how DNA packaging affects gene expression - is chromatin immunoprecipitation (ChIP), a technique that allows researchers to examine interactions between ...

Odd histone helps suppress jumping genes in stem cells, study says

A family of proteins known as histones provides support and structure to DNA, but for years, scientists have been puzzling over occasional outliers among these histones, which appear to exist for specific, but often mysterious ...

Decoding the cell's genetic filing system

A fully extended strand of human DNA measures about five feet in length. Yet it occupies a space just one-tenth of a cell by wrapping itself around histones—spool-like proteins—to form a dense hub of information called ...

DNA 'spool' modification affects aging and longevity

Research on a modified protein around which DNA is wrapped sheds light on how gene regulation is linked to aging and longevity in nematodes, fruit flies and possibly humans.

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