Each one of the cells in our body contains DNA, which provides the instructions required for our development and function. Astoundingly, a total of two meters of DNA is packaged in each cell's nucleus, just tens of microns ...
Biotechnology
Jul 15, 2021
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A study lead by SciLifeLab Fellow Simon Elsässer elucidates the mechanism of a peculiar type of heterochromatin, used by embryonic stem cells to silence 'parasitic' DNA-elements within the context of their highly dynamic ...
Cell & Microbiology
Oct 9, 2020
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Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of DNA and regulate gene expression.
Cell & Microbiology
Sep 28, 2020
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A group of scientists from CECAD has found a mechanism by which neurodevelopmental diseases concerning neurons can be explained. The loss of a certain enzyme, UBE2K, impedes the differentiation of stem cells by silencing ...
Cell & Microbiology
Jun 4, 2020
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2
The genetic material—DNA—of plants and animals (within the latter humans) is stored inside the cell, and DNA packing is guaranteed by proteins called histones. Furthermore, histones play a key role in regulating the activation ...
Molecular & Computational biology
Apr 17, 2020
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A study undertaken by an international team led by Ludwig-Maximilians-Universitaet (LMU) in Munich molecular biologist Axel Imhof sheds new light on the mechanisms that control the establishment of epigenetic modifications ...
Molecular & Computational biology
Feb 7, 2020
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40
How can human cells pack 3-meter-long DNA into their tiny nuclei and unpack it only where and when it is needed? This fascinating process is far from being completely understood.
Biotechnology
Feb 5, 2020
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The genetic material of our cells—DNA—exists in a high-order structure called chromatin. Chromatin consists of DNA wrapped around histone proteins and efficiently packs DNA into a small volume. Moreover, using a spool ...
Molecular & Computational biology
Jan 23, 2020
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Researchers have used mass spectroscopy to determine the absolute copy numbers of nuclear proteins and histone modifications in the Drosophila embryo. The results provide new insights into the mechanisms of animal development.
Plants & Animals
Oct 22, 2019
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4
By using proteins that naturally bind and arrange DNA inside cells, a KAUST-led team has devised a plug-and-play strategy for building stable, custom-designed nanostructures.
Nanomaterials
Oct 14, 2019
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