The "Goldilocks effect" in fruit fly embryos may be more intricate than previously thought. It's been known that specific proteins, called histones, must exist within a certain range—if there are too few, a fruit fly's ...
Cell & Microbiology
Jun 12, 2014
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0
In the cell nucleus, histones play a crucial role packaging DNA into chromatin. Histones are however very sticky to both DNA and RNA, so to ensure they are transported to the cell nucleus after synthesis and bind to the right ...
Cell & Microbiology
Apr 14, 2021
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18
The DNA in the 23 pairs of chromosomes in each of the billions of cells of the human body is so tightly packed that it would measure six feet in length if stretched end to end. A genome of this size can squeeze into a cell's ...
Cell & Microbiology
Apr 9, 2009
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Turning genes on and off is an intricate process involving communication between many different types of proteins that interact with DNA.
Biochemistry
May 17, 2018
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6
The packaging of a gene has a major impact on its functional state and must be precisely controlled. A novel blend of methods has unveiled the architecture of a large protein complex that modulates DNA packing, and hints ...
Cell & Microbiology
Sep 16, 2013
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Researchers at the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, have developed a system to accelerate the discovery of chemical compounds that inhibit an enzyme ...
Biochemistry
Sep 6, 2018
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47
Local modifications in histone proteins alter DNA packing density in the cell nucleus to regulate gene activity. They also form the basis of a code in which the significance of a given pattern or motif depends on its broader ...
Biotechnology
Jan 28, 2016
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5
Researchers at the University of Warwick have uncovered the mechanism that allows plants to pass on their 'memories' to offspring, which results in growth and developmental defects.
Plants & Animals
Dec 1, 2020
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35
A study from the University of North Carolina at Chapel Hill has identified a key player in a molecular process essential for DNA replication within cells.
Cell & Microbiology
Oct 22, 2009
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Since the time of ancient Egypt, humans have been making and breaking secret codes to retain and gain critical information. Human life itself is based upon a genetic code of DNA or RNA sequences which cells read and translate ...
Biochemistry
Nov 8, 2018
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