Cancer drops sparse chemical hints of its presence early on, but unfortunately, many of them are in a class of biochemicals that could not be detected thoroughly, until now.
Biochemistry
May 7, 2018
0
217
The parasite Trypanosoma brucei, which causes African sleeping sickness, is like a thief donning a disguise. Every time the host's immune cells get close to destroying the parasite, it escapes detection by rearranging its ...
Cell & Microbiology
Apr 15, 2009
1
0
Many processes in the body are regulated by the functions of proteins. For example, almost all molecules—such as DNA, proteins, oligosaccharides, and small bioactive molecules—are generated by enzymes. However, changes ...
Biochemistry
Aug 10, 2021
0
311
Pity the glycan—these complex sugar molecules are attached to 80% of the proteins in the human body, making them an essential ingredient of life. But this process, known as glycosylation, has been somewhat overshadowed ...
Biochemistry
Sep 17, 2020
0
97
Cell therapies hold great promise for revolutionizing the treatment of cancers and autoimmune diseases. But this multibillion-dollar industry requires long-term storage of cells at super-cold cryogenic conditions, while ensuring ...
Biochemistry
Feb 14, 2020
0
142
Vanderbilt University researchers have discovered how a protein pump distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
Biochemistry
May 31, 2019
0
15
The structure of the critical quality control checkpoint enzyme that oversees the production of thousands of secreted glycoproteins has been solved by a fruitful collaborative effort at Diamond Light Source. The study, recently ...
Biochemistry
Jul 25, 2017
0
90
A Purdue University biochemist has developed a novel method for detecting certain types of proteins that serve as indicators for cancer and other diseases.
Bio & Medicine
Nov 15, 2016
0
182
For the first time, scientists at The Scripps Research Institute (TSRI) have solved the structure of the biological machinery used by a common virus to recognize and attack human host cells.
Cell & Microbiology
Apr 26, 2016
0
32
(Phys.org) —A team of researchers working at the Sloan Kettering Institute for Cancer Research has succeeded in building a glycoprotein from scratch. It marks an enormous step forward, the team reports in their paper published ...
Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending extracellularly, the extracellular segments are often glycosylated. Glycoproteins are often important integral membrane proteins, where they play a role in cell–cell interactions. Glycoproteins also occur in the cytosol, but their functions and the pathways producing these modifications in this compartment are less well-understood.
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