Sleeping sickness parasite uses multiple metabolic pathways

Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a study published December 27 in the open-access journal PLOS Pathogens by David Horn of ...

Cellular clean-up crews linked to how body handles sugar

How our bodies handle glucose—the simple sugar that provides energy from the food we eat—appears to be intertwined with how cells keep themselves functioning normally, according to new University of Chicago research.

Bears' seasonal hibernation linked to changes in gut microbes

Each year, as bears prepare to hibernate, they gorge themselves on food to pack on fat. And yet, despite the rapid weight gain, the animals somehow avoid the health consequences so often associated with obesity in humans. ...

Fat turns from diabetes foe to potential treatment

A new weapon in the war against type 2 diabetes is coming in an unexpected form: fat. Researchers have discovered a new class of potentially therapeutic lipids, called fatty-acid esters of hydroxy fatty acids (FAHFAs). These ...

Hippo 'crosstalk' may be vital to tumor suppression

Think of a waterfall, and you might see why cell-signaling pathways are important to cancer research. As water cascades, it impacts everything downstream. And everything upstream affects the waterfall.

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