New biomarker for severe COVID-19

During the pandemic, it has become evident that people with cardiovascular disease and obesity are at much higher risk of developing very severe, even fatal COVID-19 disease. Researchers at Karolinska Institutet have identified ...

Insulin signaling suppressed by decoys

In a discovery that may further the understanding of diabetes and human longevity, scientists at Scripps Research have found a new biological mechanism of insulin signaling. Their study, involving the roundworm C. elegans, ...

Gut bacteria keeps bears healthily obese

The summer sun pokes its way through the pine trees to strike the forest floor, where a bear is feasting on blueberries. She can easily get through 50 kilograms a day.

'Pillownauts' help future manned missions to Mars

The 3-day bed rest study is being carried out in Nottingham in parallel to a 60-day bed rest study by the European Space Agency at the MEDES facility in Toulouse, France. Bed rest is a tried and tested way to measure the ...

Bears not bothered by diet high in saturated fats

Campgrounds and cottages are getaways for humans. They are also locations where grizzly bears are acquiring appetites for human foods that are high in saturated fats. Diets high in saturated fats are associated with many ...

Sugar sponges sop up and release glucose as needed

Many diabetes patients must inject themselves with insulin, sometimes several times a day, while others take medications orally to control blood sugar. The injections, as well as the side effects from both regimens, can be ...

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Insulin resistance

Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.

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