CRISPR-BEST prevents genome instability

Even though CRISPR technologies allow for better manipulation of genomes with many positive effects on modern drug development and the discovery of new and better antibiotics, significant problems such as genome instability ...

An effective sweeper closes DNA replication cycling

DNA replication is essential for living organisms to faithfully deliver genetic information from parental cells to daughter cells. Many proteins are assembled on the parental DNA to work as replication machineries. Among ...

A cause of possible genetic problems in mitochondria is revealed

A group of researchers from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) has revealed the importance of eliminating any excess of defective products that might have accumulated in the mitochondria, ...

How male germ cells avoid genome instability

A group of researchers at Osaka University reported the function of GTSF1 in male germ cells. The study, which can be read in EMBO Reports, shows that GTSF1 is an essential factor for secondary piRNA biogenesis by regulating ...

Team discovers new mechanisms for DNA stability

Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine have discovered that in eukaryotic cells, the proximity of the genes to the pores in the nuclear membrane ...

Protein complex prevents genome instability

An international collaboration between Osaka University and the Friedrich Miescher Institute for Biomedical Research (FMI) in Switzerland is investigating the repair process of a serious form of DNA damage that can lead to ...

Epigenetic repression suppresses genomic instability

Susan Gasser and her group at the FMI have found the pathway through which eukaryotic organisms protect their genomes from rearrangements and deletions that arise from repetitive DNA. Human genomes, like those of simple animals ...

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