(Phys.org)—Genome editing for purposes of replication and repair is handled by enzymes called endonucleases, which cleave DNA strands at very specific sites. These are called "restriction sites," composed of palendromic ...
An international research team has discovered that a previously overlooked repetitive DNA element known as Long Interspersed Nuclear Element (L1) helps maintain neural progenitor cells, and thus plays an important role in ...
Cell & Microbiology
Feb 14, 2024
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A recent Northwestern Medicine study published in the Journal of Cell Biology has identified new mechanisms that cause genomic or chromosomal instability during cell division, findings that may improve the development of ...
Cell & Microbiology
Jun 13, 2023
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A research team led by Dr. Gary Ying Wai Chan from the School of Biological Sciences at The University of Hong Kong (HKU), has revealed the function of a unique enzyme, ANKLE1. ANKLE1 acts on chromatin bridges that are trapped ...
Cell & Microbiology
Apr 18, 2023
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CRISPR/Cas9 is a precise gene editing technique whose development by Jennifer A. Doudna and Emmanuelle Charpentier was recognized with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors," CRISPR allows ...
Biotechnology
Aug 9, 2022
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There are many ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops. These are three-stranded structures ...
Molecular & Computational biology
Feb 8, 2022
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New published research from the College of Veterinary Medicine shows that heightened levels of genomic instability can prove fatal to female embryos in mice.
Biotechnology
Feb 21, 2019
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A group of researchers from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) has revealed the importance of eliminating any excess of defective products that might have accumulated in the mitochondria, ...
Cell & Microbiology
Jan 3, 2019
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Chromosomes undergo precise structural changes at a molecular level during the different phases of cell division. These changes occur at a high level of accuracy to prevent genome instability. Genome instability resulting ...
Cell & Microbiology
May 27, 2022
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Cancer is a devastating disease and is the second leading cause of death in the U.S. One of the hallmarks of cancer is genomic instability, or the tendency to accumulate mutations and damage to the DNA that leads to genome ...
Cell & Microbiology
Sep 23, 2021
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