Looking beyond genes to explain blood cells' fates

Scientists often talk about cell fate and commitment in terms of mechanisms that control gene expression (transcription factors, chromatin remodeling, etc.). But by studying Diamond-Blackfan anemia (DBA), rare genetic blood ...

Cell contacts in embryonic development determine cellular fate

The average human has about 37.2 trillion cells. But cells are differentiated for thousands of different functions. How does a cell 'know' which function to fulfill? In a paper published today in Developmental Cell, the group ...

Neural stem cells control their own fate

To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in. A research group at the University of Basel now describes for the first time a mechanism by which hippocampal ...

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