Tracing a plant chemistry puzzle to its roots

Graduate student Colin Kim had been making good progress on a scientific puzzle that had fascinated him since he joined Whitehead Institute Member Jing-Ke Weng's lab, trying to understand how coumarin synthase (COSY), an ...

Metal-organic frameworks behave like enzymes in catalysis

The construction of substrate-specific nanopockets in metal-organic frameworks (MOFs) with allosteric effects has been demonstrated to facilitate the formation of the transition state in catalytic reactions, as enzymes do.

Stabilizing chromosomes to tackle tumors

Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off altogether. An enzyme called ...

Researchers demonstrate enzyme-MOF flow reactor

Enzymes are considered true multi-functional talents. They accelerate many chemical reactions as catalysts. In organisms, they are involved in vital processes. In technology and industry, they can be used as tools of white ...

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