The tools of biochemistry have finally caught up with lactose repressor protein. Biologists from Rice University in Houston and the University of Florence in Italy this week published new results about "lac repressor," which ...
Biochemistry
Sep 22, 2009
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Researchers have discovered the two-step process that activates an essential human enzyme, called Suv39h1, which is responsible for organizing large portions of the DNA found in every living cell.
Biochemistry
Feb 18, 2016
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17
Diversity is good, especially when it comes to antibodies. It's long been known that a gene assembly process called V(D)J recombination allows our immune system to mix and match bits of genetic code, generating new antibodies ...
Cell & Microbiology
Sep 13, 2019
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59
(Phys.org)—In certain toy racecar tracks, sneaky players can flip a switch, trapping their opponents' vehicles in a loop of track. Cells employ a less subtle approach: they change the track's layout. In a study published ...
Cell & Microbiology
Sep 28, 2012
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Protein factors are responsible for organizing chromosomes inside the nucleus in three dimensions (3D), forming a shape like a gift bow, with proteins aggregating as the central 'knot' holding the ribbon-like loops of DNA ...
Cell & Microbiology
Dec 10, 2015
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In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on key biological events that may eventually be manipulated to provide new disease treatments.
Cell & Microbiology
Jun 7, 2012
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Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the challenges of molecular biology ...
Cell & Microbiology
Mar 29, 2023
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64
Contrary to what was thought, sequences of DNA called enhancers – which control a gene's output – find their targets long before they are activated during embryonic development, scientists at the European Molecular Biology ...
Cell & Microbiology
Jul 3, 2014
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Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei, and DNA tension plays a surprising role in this.
Cell & Microbiology
Apr 19, 2023
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89
DNA is a molecular manual that contains instructions for building life. And, like any manual, DNA isn't all that useful if it remains unopened and unread. In order to transcribe DNA, the enzyme RNA polymerase, or RNAP, must ...
Molecular & Computational biology
Jan 10, 2019
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