Dynamic twists and loops can enable DNA to modulate its function

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are known to influence every ...

Building better base editors

CRISPR-based gene editing has potential therapeutic benefits but also some technical shortcomings. One set of these gene editing tools, base editors, can rewrite the four individual DNA letters, or bases— A, C, T or G—which ...

DNA base editing induces substantial off-target RNA mutations

In a study published in Nature on June 10, researchers from Dr. Yang Hui's Lab at the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), and collaborators from the CAS-MPG Partner Institute for Computational ...

Rapid, cost-effective genetic screening within reach

CU Boulder researchers are developing new techniques for faster, more cost-effective single-molecule DNA sequencing that could have transformative impacts on genetic screening, paving the way for advances in vaccine development, ...

Virology: A marker for a cancer-causing virus

(Phys.org)—Depending on the strain, or genotype, of the human papillomavirus (HPV) (see image), the lesions it causes can range from relatively benign to cancer-causing. Differentiating between lesions caused by low-risk ...

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