DNA-damaging agents, or "DDAs," make up the most widely used group of cancer drugs. Yet their therapeutic success has been curtailed by drug resistance—either present in cancer cells from the disease onset or arising during ...
Molecular & Computational biology
Oct 29, 2018
0
48
If we really want to know how our body's cells work—or don't work, in the case of disease—we might need to look beyond their genes and even beyond the proteins they are made of. We may need to start going through the ...
Biotechnology
Oct 22, 2018
0
66
UC San Francisco scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
Biotechnology
Jul 20, 2018
0
409
Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets ...
Cell & Microbiology
Jul 2, 2018
0
39
For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth ...
Cell & Microbiology
Jun 29, 2018
0
113
Almost every cell in the human body, from beating heart cells to bacteria-gobbling immune cells, is powered by chemical energy produced by specialized organelles called mitochondria. The process of energy generation creates ...
Cell & Microbiology
May 3, 2018
0
17
New research by scientists shows that when cellular barriers are exposed to metal nanoparticles, cellular messengers are released that may cause damage to the DNA of developing brain cells. The discovery may have implications ...
Bio & Medicine
Apr 4, 2018
0
30
A groundbreaking and surprising discovery provides a major conceptual change of what is most important to cells: the fidelity of the DNA transcription process - accurately copying the DNA message into RNA, the precursor to ...
Cell & Microbiology
Oct 4, 2017
0
12
Is it better to do a task quickly and make mistakes, or to do it slowly but perfectly? When it comes to deciding how to fix breaks in DNA, cells face the same choice between two major repair pathways. The decision matters, ...
Cell & Microbiology
Sep 20, 2017
0
249
To fight infections cells in the immune system play a dangerous game with their own genes. Damaging genes allows B cells to make antibodies that are specifically equipped to target to specific causes of illness, but damaging ...
Cell & Microbiology
Sep 13, 2017
0
2
