How DNA damage affects Golgiā€”the cell's shipping department

In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by ...

One protein, two important roles

The molecular pathways involved in the cell cycle are complex and difficult to control. Better understanding of cell control mechanisms, and why they go wrong in cancer, could help open the door to more effective cancer drug ...

Molecular engines star in new model of DNA repair

Our health depends in large part upon the ability of specialized enzymes to find and repair the constant barrage of DNA damage brought on by ultraviolet light radiation and other sources. In a new study NYU School of Medicine ...

Histone exchanger comes into focus

The packaging of a gene has a major impact on its functional state and must be precisely controlled. A novel blend of methods has unveiled the architecture of a large protein complex that modulates DNA packing, and hints ...

Whales feel the (sun)burn

Whales have been shown to increase the pigment in their skin in response to sunshine, just as we get a tan.

How DNA repair helps prevent cancer

The biological information that makes us unique is encoded in our DNA. DNA damage is a natural biological occurrence that happens every time cells divide and multiply. External factors such as overexposure to sunlight can ...

Laser pulses reveal DNA repair mechanisms

A new straightforward method enables monitoring the response of nuclear proteins to DNA damage in time and space. The approach is based on nonlinear photoperturbation.

'Cowcatcher' enzyme fixes single-strand DNA

Every time one of your cells divides, it exposes its most essential component to great danger: its genome, the sum total of all its genetic information, embodied in the double-stranded helix of DNA. Prior to cell division, ...

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