DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species. To detect and repair DNA lesions, cells have evolved DNA damage response. ...
Cell & Microbiology
Feb 27, 2019
0
4
For more than a decade, scientists have worked to understand the connection between colibactin, a compound produced by certain strains of E. coli, and colorectal cancer, but have been hampered by their inability to isolate ...
Biochemistry
Feb 14, 2019
0
59
The DNA replication process in which cells divide to create new cells also triggers repair of DNA damage, researchers from the University of Copenhagen report in a new study. The researchers studied extracts from frog eggs, ...
Cell & Microbiology
Jan 23, 2019
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28
A team led by researchers at Baylor College of Medicine and the University of Texas at Austin has applied an unconventional approach that used bacteria to discover human proteins that can lead to DNA damage and promote cancer. ...
Cell & Microbiology
Jan 10, 2019
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253
When a building is damaged, a general contractor often oversees various subcontractors—framers, electricians, plumbers and drywall hangers—to ensure repairs are done in the correct order and on time.
Biotechnology
Dec 13, 2018
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73
Since Carnegie Institution's Barbara McClintock received her Nobel Prize on her discovery of jumping genes in 1983, we have learned that almost half of our DNA is made up of jumping genes—called transposons. Given their ...
Biotechnology
Nov 1, 2018
0
13
DNA-damaging agents, or "DDAs," make up the most widely used group of cancer drugs. Yet their therapeutic success has been curtailed by drug resistance—either present in cancer cells from the disease onset or arising during ...
Molecular & Computational biology
Oct 29, 2018
0
48
DNA and RNA are naturally polarised molecules containing electric dipole moments due to the presence of a significant number of charged atoms at neutral pH. Scientists believe that these molecules have an in-built polarity ...
Condensed Matter
Aug 21, 2018
0
10
UC San Francisco scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
Biotechnology
Jul 20, 2018
0
409
Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets ...
Cell & Microbiology
Jul 2, 2018
0
39
